Longevity and vitality at the cellular level

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme that supports mitochondrial health in our body's cells. Like other coenzymes, NAD+ can be derived from vitamins (in this case, synthesized from vitamin B3). Healthy NAD+ levels help fuel mitochondria, enabling optimal cell performance and waste removal. NAD+ provides crucial assistance to enzymatic processes that enable DNA repair and gene expression. Its fundamental role in cellular health means NAD+ affects every body system and is fundamentally involved in neuroplasticity and defense against neurodegenerative disease; aerobic capacity and exercise endurance; arterial health; repair of sun-damaged skin; stress response; and much more.

Our formulation is firmly rooted in scientific research to date. Over the past half-decade, we've spent thousands of hours analyzing research studies — human, animal, and in vitro — to identify the most reliably safe and effective methods of boosting NAD+ in the body. We also consulted with doctors, nutritionists, and formulation specialists during our research to benefit from varied expertise on the subject. At the same time, we spent many hundreds of hours assessing NAD+ supplements that aim to improve cellular health and longevity. The goal of all this was to offer the best advice and product recommendations to consumers, based on available products at the time. But too often, we saw NAD+ boosters using supplement forms or dosing that lacked scientific evidence as to their effectiveness or safety. Many companies choose one precursor or the other in an unnecessarily small dose, while others rely on exciting and promising forms, delivery methods, or added ingredients that have simply not been studied rigorously in humans. While those approaches may have merit, there is a real lack of scientific data to help you understand their safety and effectiveness at this time.

We think you deserve more reliability as you endeavor to extend your healthspan, so we adhere to the highest standards when choosing our ingredients as well as their form and dosage. Because we are guided purely by what human studies show to be effective for various anti-aging goals, we include both NMN and NR in our supplement while avoiding NAD+ as an ingredient. (There is currently little scientifically supported rationale for supplementing directly with NAD+; it’s not bioavailable enough.) Because human studies to date have almost entirely used capsules, so do we. And our research extends further to supporting ingredients that can amplify the effects of our NAD+ precursor supplementation. Our dedication to following the scientific data means you can be confident that our formula is the most reliably safe and effective on the market.

We include both of these NAD+ precursors for the same reason that we exclude NAD+ itself as an ingredient; our formula is based on what human studies show to be effective and safe for increasing NAD+ levels in the body. Supplementing with NAD+ precursors is much more effective than supplementing with NAD+ itself. At the same time, while supplemental NMN and NR both boost NAD+ levels, the most compelling research to date has not shown that their effects on human health are identical from supplementation.

For example, human studies of NR have demonstrated its neuroprotective properties in a way that human studies using NMN have yet to replicate. Meanwhile, NMN has been shown to increase aerobic capacity, improve sleep, and fend off harmful DNA damage to skin, and there haven't been human studies of NR that show these effects. With several more years of clinical research, it's possible that this picture looks different, but until then — and because of the complexities of bioavailability and how these precursors enter into the main salvage pathway to produce NAD+ — we conclude that it's most reliable to provide both to you.

Many people notice positive effects on energy levels, vitality, and even cognitive sharpness immediately after their first several doses of NAD+ Support. But as the intent of this supplement is to improve your healthspan over time, the full effects of improving your mitochondrial health play out over a longer period. You will likely notice effects like improved physical endurance, better sleep, and improved blood pressure after several weeks or months of use. Continued use over months and years supports improved cellular metabolism and DNA repair that can help protect body systems from age-related disease.

We formulated NAD+ Support based on what human studies indicated would be reliably effective and safe for healthy adults. But no two people are the same, and you should speak to your doctor before introducing this supplement or any other new supplement to your routine. Only through discussion with your trusted health professional can you arrive properly at a conclusion that the supplement is safe and recommendable for you, based on your underlying health and any medications or supplements you are already taking.

No, there is no evidence to suggest that cycling NAD+ Support would be useful or that continued use would be unsafe or counterproductive. Unlike supplements that provide only NAD+ precursors, our formula protects against methyl donor depletion and the risk of accumulating unhelpful derivatives that could otherwise elevate cholesterol and be detrimental to your health. NAD+ Support is designed for beneficial long-term use.

Storing your NAD+ Support in the refrigerator is advisable if storing for months at a time, if humidity is significant, or if temperatures otherwise wouldn't remain stably below 76 degrees Fahrenheit. If in doubt, the refrigerator is a safe choice for storage. But if you are using the supplement as suggested over the course of a month and live in a place where the storing temperature will not rise higher than 76 degrees, then refrigeration isn't necessary.

We recommend taking NAD+ Support each day in the morning.

You can take this supplement with or without food. Water is all that's required.

We formulated NAD+ Support to align with human studies that indicate it will offer the greatest reliability and the widest array of benefits tied to longevity, so we recommend the full suggested dose. However, taking a partial serving will not be harmful in any way and should still be beneficial; human studies indicate that NMN and NR boost NAD+ levels in a dose-dependent way, with larger doses promoting a larger boost in NAD+. Lower doses boost NAD+ to a lesser degree. Some human studies show positive benefits from what amounts to a third or two-thirds of our suggested dose.

At this time, we do not ship outside of the United States. We do, however, ship to Army post office addresses.